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viiTime Dependence and Concentration of Cellular Uptake of Hematoporphyrin Monomethyl Ether in Nasopharyngeal Carcinoma Cells
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LI Bu-hong 1,2, YANG Fu-wen 3, ZHANG Zhen-xi 1, XIE Shu-sen 2
(1.The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shanxi, China£»2. Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou 350007,Fujian, China£»3.Department of Otorhinolaryngology, Fuzhou General Hospital of the PLA , Fuzhou 350025 , Fujian, China£©
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Abstract£ºTime dependence and concentration of cellular selective uptake of new photosensitizer Hematoporphyrin monomethyl ether (HMME) in human nasopharyngeal carcinoma cell line CNE have been studied and determined by incubated CNE cells with HMME. Experimental results show that the peak emission fluorescence at the wavelength of 615 and 675 nm characterized the selective accumulation of HMME in CNE cells. The curve for time dependence of HMME in CNE cells indicate that the highest uptake peak appear in about 140 mins after incubation. When the concentration of HMME for incubated CNE cells under 32 (g/ml, the fluorescence intensity versus HMME concentration reveals an obvious linearity. These results can be used to improve the efficiency of photodynamic therapy and the accuracy of optical diagnosis for nasopharyngeal carcinoma with HMME.
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