Abstract: Objective :To observe the therapeutic effect of recalcitrant condyloma acuminatum in urethral orifice ,ostium vaginae，anus and crissum treated with Nd:YAG laser.Methods:61 patients with condyloma acuminatum in privileged sites were divided into experimental group and control group in random.Experimental group was 31 patients treated with Nd:YAG laser，while control group was 30 patients treated with CO2 laser. Follow up a case by regular visits to half a year and observe two groups of the healing state of raw surface,cure rate and recurrence rate.Results:The cure rate was 80.64% after experimental group was treated with Nd:YAG laser once.It was higher than that of control group,56.67%( x2=4.087 , P <0.05).But no difference could be found in the con-cure rate of two groups (x2=1.198, P >0.05).The recurrence rate in experimental group was 22.58%,which was lower than that in control group，46.67%. There was remarkable difference between two groups (x2=3.918，P <0.05).Five days after the laser treatment ,the healing rate of raw surface in experimental group was 45.16%,which was higher than that in control group,20.00%( x2=4.490, P <0.05).Seven days after the treatment , the healing rate in experimental group,87.09% was higher than that in control group,60.00%( x2=4.469, P <0.05).The healing rate in experimental group was 100% in ten days after the laser treatment,while the healing rate in control group was 83.33%.There was marked qualitative difference between the two groups(P =0.024<0.05).Conclusion:Nd:YAG laser had proven to be safe and effective in treating condyloma acuminatum located in raw surface.The raw surface heal fast after laser treatment and the recurrence rate was low.