Abstract: Accumulation ,distribution and elimination of lead in Carassius auratus and effects of SDBS,a kind of negative ion surfactant,on accumulation,distribution and elimination of lead in Carassius auratus were studied.The results showed that accumulation of lead in different tissue of fish was different. The content order of lead in different tissues was innards>head>paunch muscle>back muscle;The content of lead in fish increased with time.SDBS slowed down the accumulation and elimination of lead in fish. The elimination rate of lead in fish was slower than the accumulation rate.