ABSTRACT：Objective：To observe and evaluate the clinical therapeutic effects of the 650nm laser acupoint irradiation on benign prostatic hyperplasia (differential diagnosis in Chinese Medicine as deficiency of kidney-yang). Methods：Thirty patients with benign prostatic hyperplasia (BPH) received laser irradiation of wavelength 650nm on Huiyin (CV1),Guangyuan (CV 4) and Shensu (UB23). Another thirty BPH patients were randomLy selected as controls and acupuncture was applied on their Shensu (UB23), Zhibian (UB 54), Guangyuan (CV 4), Mingmen (GV 4), Zusanli (ST 36), Pishu (UB 20), Sanyinjiao (SP 6), Ciliao (UB32), etc. for clinical comparative observations. Results：Laser irradiation on the acupoints and acupuncture both had good therapeutic effects on benign prostatic hyperplasia. There were significant differences between the pre and post treatment scores on symptoms and urodynamics in both groups (p<0.05). However, the clinical efficacies of the two groups were not significantly different (p>0.05). Conclusion:The 650 nm laser acupoint irradiation is one of the effective treatments on benign prostatic hyperplasia (deficiency of kidney-yang type) and worth further in-depth investigations.