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Study on the correlation between IL-10 promoter，IL-1ra gene polymorphism and SLE in Chinese Han population of Hunan province
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WANG Fu-yan XIE Hong-fu LUO Qi-zhi ZHA Guo-zhang YU Ping
（Department of Immunology, Xiang Ya School of Medicine, Central South University, Changsha, 410078）
Corresponding author: Yu Ping, Email: yuping1953@sina.com
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Abstract: Objective: To study on the gene polymorphisms of interleukin-10 (IL-10) promoter and interluekin-1 receptor antagonist (IL-1ra) in the Han nationality of Hunan and test the correlation between these genes and Systemic lupus erythematosus (SLE) patients. Methods:polymerase chain reaction and restriction enzyme cleavage were used to analyze the gene polymorphisms. Results :There are gene polymorphisms in IL-1ra and IL-10 promoter in the Hunan Han groups.IL-1RN*1 frequency of SLE patients increased significantly (P( 0.05, RR = 5) than that of normal controls. A significant increase was found in the frequencies of -597*A and
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