Abstract: The full length cDNA of a human novel gene was cloned from human fetal cDNA library, and was named zinc-finger protein 418 (ZNF418) as approved by the Human Gene Nomenclature Committee. ZNF418 gene is located on Chromosome 19q13.43, and encodes a protein consisting of 676 amino acid residues and containing a KRAB motif and 17 tandem C2H2-type zinc-finger motifs. Northern blot results shows that the gene is expressed in multiple examined adult tissues. Subcellular location study indicates that ZNF418–EGFP fusion protein is mostly distributed in the nucleus. These results suggest that ZNF418 is a potential transcriptional factor.