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Effect of Cellular Apoptosis on Immunologic Function Change of Peripheral Blood between Esophageal Carcinoma Patient before and after Operation
LIN Jue-longa, XIE Yang-mina , SHEN Zhi-zhongb , PIAO Zhong-xiana,
HONG Chao-qunc, YANG Wei-pingc
( Shantou University a . Medical College ; b.First Affiliated Hospital of Medical College ;
c. Tumor Hospital of Medical College , Shantou 515031，Guangdong，China )
Abstract: To study apoptosis of peripheral blood cell of esophageal carcinoma patients. Peripheral blood cell DNA content，CD4，CD8 and CD16/56 count were analyzed with flow cytometry. Blood samples were collected before surgical operation and 10 days～14 days after operation from 70 patients who had oesophagectomy. The results showed that apoptosis (Apo) was different in peripheral blood cells before and after operation (P ＜0.05, but S-phage fraction (SPF) or proliferation index (PI) was not (P ＞0.05). A significant difference between the groups was noted for CD4/ CD8 ratio or the percentage of CD16/56 (P ＜0.001). Our data show that increasing cellular apoptosis before operation might be beneficial in balancing malignant proliferation of tumor cell, and higher level of CD8 and NK（ natural killer cells ）might assist this balance in peripheral blood cell. But after operation, tumor load of the patient was alleviated, immunologic function was restored to normal state, and cellular apoptosis was decreased accordingly.
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