激光生物学报摘要, 更新时间: 2007年10月13日
  由美国生科集团 (BVTech, Inc.) 主办
  
湖南汉族人群IL-10启动子和IL-1ra基因多态性与SLE相关性研究
激光生物学报摘要 2007-3

王芙艳 李官成 谢红付 罗奇志 查国章 余平* ( 中南大学湘雅医学院免疫学教研室，长沙，410078)

摘 要：目的：研究湖南汉族人群IL-10启动子和IL-1受体拮抗剂（IL-1ra）的基因多态性，探讨IL-10启动子和IL-1ra基因多态性与SLE疾病的关系。方法：PCR和限制性内切酶酶切分析SLE患者（n=83）和正常对照人群（n=125）IL-10启动子和IL-1ra基因多态性，对基因频率进行分析。结果：湖南汉族人群IL-1ra及IL-10启动子基因具有多态性；SLE患者IL-1RN*1等位基因的频率显著高于正常对照组（P(0.05，RR=5）；SLE患者IL-10启动子区-597位*A、-824位*T和ACC亚型的基因频率高于正常对照组(P(0.001)。结论：SLE患者IL-1RN*1的基因频率、IL-10启动子区-597位和-824位的基因多态性与正常人比较有显著差异，提示以上基因可能与SLE的发病有一定相关性。


Study on the correlation between IL-10 promoter，IL-1ra gene polymorphism and SLE in Chinese Han population of Hunan province

WANG Fu-yan XIE Hong-fu LUO Qi-zhi ZHA Guo-zhang YU Ping （Department of Immunology, Xiang Ya School of Medicine, Central South University, Changsha, 410078） Corresponding author: Yu Ping, Email: yuping1953@sina.com

Abstract: Objective: To study on the gene polymorphisms of interleukin-10 (IL-10) promoter and interluekin-1 receptor antagonist (IL-1ra) in the Han nationality of Hunan and test the correlation between these genes and Systemic lupus erythematosus (SLE) patients. Methods:polymerase chain reaction and restriction enzyme cleavage were used to analyze the gene polymorphisms. Results :There are gene polymorphisms in IL-1ra and IL-10 promoter in the Hunan Han groups.IL-1RN*1 frequency of SLE patients increased significantly (P( 0.05, RR = 5) than that of normal controls. A significant increase was found in the frequencies of -597*A and


 

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