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枯草芽孢杆菌JA-206对皮肤癣菌抑制作用的研究
激光生物学报摘要 2007-5
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吕树娟1, 方海红1 , 刘 静2 , 王明丽1
（1.安徽医科大学微生物学教研室, 合肥 230032;
2.中国科学院离子束生物工程学重点实验室,合肥 230031）
摘 要：低能离子诱变筛选获得的枯草芽孢杆菌JA－206株的发酵粗提液对红色毛癣菌和须毛癣菌有较强的抑菌或杀菌作用，粗提液经高温、蛋白酶处理后仍然有较高的稳定性，将JA－206粗提液经多步分离纯化，得到三种单一纯化产物抗菌肽AFP1、AFP2和AFP3，其中AFP1和AFP3对两种皮肤癣菌显示出明显的抑菌或杀菌作用。
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The Study of Antagonism of Bacillus subtilis JA-206 against Dermatophytes
LV Shu-Juan1, FANG Hai-Hong1, LIU Jing2, WANG Ming-Li1
(1.Department of Medical Microbiology, Anhui Medical University, Hefei 230032; 2. Key Laboratory of Ion Beam Bioengineering,Chinese Academy of Sciences , Hefei 230031)
Abstract：The fermentation crude extract of Bacillus subtilis JA－206 screened by the technology of ion implantation can effectively inhibit or kill T. purpureatum and T. mentagrophytes. The crude extract is stable against heat and enzyme. Three types of antimicrobial peptides, named AFP1、AFP2and AFP3 were purified from the crude extract of Bacillus subtilis JA-206. AFP1 and AHP3 both had strong inhibitory activity against two kinds of dermatophytes.
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Bioinformatics,
sequence analysis; GCG; Life Science News; Drug Discovery.
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