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停止生长的细菌可能进入休眠状态, 而并非死亡。新发现的接触依赖性抑制剂 A (Contact-dependent inhibitor A, CdiA), 一种细胞表面的大分子蛋白, 和共同分泌的家族成员CdiB组成生长抑制系统。本研究结果可能有助于慢性疾病的治疗, 譬如尿道 感染。
Contact-Dependent Inhibition of Growth in Escherichia coli
Stephanie K. Aoki, Rupinderjit Pamma, Aaron D. Hernday, Jessica E. Bickham, Bruce A. Braaten, David A. Low*
Bacteria have developed mechanisms to communicate and compete with each other for limited environmental resources. We found that certain Escherichia coli, including uropathogenic strains, contained a bacterial growth-inhibition system that uses direct cell-to-cell contact. Inhibition was conditional, dependent upon the growth state of the inhibitory cell and the pili expression state of the target cell. Both a large cell-surface protein designated Contact-dependent inhibitor A (CdiA) and two-partner secretion family member CdiB were required for growth inhibition. The CdiAB system may function to regulate the growth of specific cells within a differentiated bacterial population.
Source: Science, Vol 309, Issue 5738, 1245-1248, 19 August 2005
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