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Cnga2 突变导致小鼠丧失性和争斗行为
2005-11-8
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过去认为,啮齿目动物通过一个叫vomeronasal 的结构器官辨别费洛蒙(pheromone), j进而影响他们的性和社会行为。现在Mandiyan 和 Shah发现, 主要溴觉系统在其中充当一个关键的角色。雄鼠在缺失主溴觉上皮细胞CNGA2基因后, 便丧失交配与争斗行为.
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Nature Neurosci. Doi:10.1038/nn1589 (2005)
Deficits in sexual and aggressive behaviors in Cnga2 mutant mice.
Mandiyan VS, Coats JK, Shah NM.
Odors detected by the vomeronasal organ or the main olfactory epithelium (MOE) trigger social behaviors in many animals. It is unknown whether MOE neurons detect cues that initiate mating or aggression. We demonstrate that mice lacking functional CNGA2 (cyclic nucleotide-gated channel alpha2), which is required for odor-evoked MOE signaling, fail to mate or fight, suggesting a broad and essential role for the MOE in regulating these behaviors.
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Bioinformatics,
sequence analysis; GCG; Life Science News; Drug Discovery.
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